Genetic variation in Myosin 1H contributes to mandibular prognathism

Genetic variation in myosin 1H contributes to mandibular prognathism.

INTRODUCTION Several candidate loci have been suggested as influencing mandibular prognathism (1p22.1, 1p22.2, 1p36, 3q26.2, 5p13-p12, 6q25, 11q22.2-q22.3, 12q23, 12q13.13, and 19p13.2). The goal of this study was to replicate these results in a well-characterized homogeneous sample set. METHODS Thirty-three single nucleotide polymorphisms spanning all candidate regions were studied in 44 pro...

Mandible in Mandibular Prognathism

Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei; Department of Orthodontics, School of Dentistry, Kaohsiung Medical University, Kaohsiung; Institute of Biomechanical Engineering, National Cheng Kung University, Tainan. Received: 3 May 2002. Revised: 3 June 2002. Accepted: 9 July 2002. Reprint requests and correspondence to: Dr. Hong-Po Chang, Department of Or...

Chin cup therapy for mandibular prognathism.

Candidate Gene Analyses of Mandibular Prognathism

Causation of a disease and a symptom generally is classified as genetic inheritance and environmental factors. A disease caused by a single gene disorder is defined as a disease that is attributed to a monogenic factor. A single gene disorder has been reported in more than 3,000 hereditary diseases. On the other hand, a polygenic or multifactorial disease is attributed to some susceptibility ge...

Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.

JAK2V617F is an acquired mutation associated with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). We tested the hypothesis that the paradox of a single disease allele associated with 3 distinctive clinical phenotypes could be explained in part by host-modifying influences. We screened for genetic variation within 4 candidate genes involved in JAK-STAT si...